RNA interference using small interfering RNAs (siRNAs) has become a mainstay of functional gene characterization and has generated over a dozen FDA-approved therapeutics and drugs in late-stage ...
Chronic hepatitis B (CHB) remains a significant global health burden, with existing therapies including nucleos(t)ide analogs, interferon, siRNA, and therapeutic vaccines demonstrating limited success ...
RNA interference-mediated gene silencing has the potential to block gene expression. A synthetic double-stranded small interfering RNA (siRNA) based on a sequence motif of 21 nucleotides from human ...
This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway will be ...
The power of small RNAs to shut down specific gene activities has now been brought to bear on an animal model of hepatitis. Mice infused with an siRNA against a cell death receptor recover liver ...
Generation Bio announces new programs using ctLNP for targeted siRNA delivery in T cell-driven autoimmune diseases, aiming for IND submission in 2026. Development of novel siRNA therapeutics using ...
In recent years, scientists have found that RNA--once thought to be little more than a bit player in the pathway from gene to protein--stands more center stage, playing a larger and more varied ...
A groundbreaking discovery about how molecules work sheds new light on a Nobel-Prize winning theory from a decade ago. New work imparts the need for caution in current clinical trials using the ...
(Nanowerk News) Using nanoparticles tagged with both a fluorescent label and a radioactive isotope of the element copper, a team of investigators at the California Institute of Technology (Caltech) ...
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